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. 2017 Sep 2;14:177. doi: 10.1186/s12974-017-0953-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — SUR1 is upregulated in astrocytes in demyelinating MS lesions. a Co-immunolabeling for SUR1 (green) and S100B (red) in a chronic active lesion; merged images are indicated; representative of 13 active, chronic active, or chronic inactive WM lesions. b, c Perivascular astrocytes, shown at low (b, right) and high (c) magnification, extend SUR1-positive processes toward nearby vessels, as visualized by chromagen (b) and fluorescent (c) immunolabeling; note absent SUR1 expression in control white matter (b, left). d, e Co-immunolabeling for GFAP (red) (d) and SUR1 (green) in a subpial/cortical demyelinating lesion, shown at low (d) and high (e) magnification; asterisk, bottom of a sulcus; representative of 6 cortical lesions; scale bars 50 μm (a, c) and 100 μm (b, d)