Fig. 11.

SUR1 and TRPM4 co-localize and co-assemble in demyelinating MS lesions. a, b Co-immunolabeling for SUR1 and TRPM4 in chronic active white matter lesions; merged images confirm co-localization of SUR1 and TRPM4 in white matter astrocytes (a) including perivascular astrocytes (b); representative of 13 active, chronic active, or chronic inactive lesions. c Co-immunolabeling for SUR1 and TRPM4 in chronic active white matter lesion, with immunoFRET confirming that SUR1 and TRPM4 co-assemble to form heteromers; representative of 13 active, chronic active, or chronic inactive WM lesions; scale bars 100 μm (a, b) and 25 μm (c)