Table 2.

List of proinflammatory and immunogenic proteins that contain exclusive Cit residues in the soluble brain proteome of AD + CVD. The proteins listed in this table have been previously implicated in inflammatory and autoimmune processes (reference(s) column)

Gene	Protein	Reference(s)	Peptide(s)	Protein residue(s)	Location	Stoicho-metrya
CNP	2′ 3′-cyclic-nucleotide 3′-phosp.	Birnbaum et al. 1996 [61]	ELRbQFVPGDEPR	224	Helix (223–226)	100
GFAP	Glial fibrillary acidic protein	Sasaki et al. 2014 [62]	SNLQIRbETSLDTK	390	Tail (378–432)	100
INA	Alpha-internexin	Lu et al. 2010 [63]	RRPPASDGLDLSQAAARbTNEYK	83	Head (1–87)	56
			KVFGDGSRbLSAR	28	Head (1–87)	100
HK1	Hexokinase-1	Norman et al. 2015 [64]	ITPELLTRbGK	331	N/A	100
			NGLSRbDFNPTATVK	53	Turn (53–55)	100
NEFL	Neurofilament light polypeptide	Jain et al. 2009 [65]	YVETPRbVHISS	23	Head (2–92)	100
ADD1	Adducin 1 (Alpha)	Rötzer et al. 2014 [66]	EDGHRbTSTSAVPNLFVPLNTNPK	479	–	67
RTN3	Reticulon-3	Chiurchiù et al. 2014 [67]	TQIDHYVGIARbDQTK	1009	–	100
AK1	Adenylate kinase isoenzyme 1	Tüzün et al. 2007 [68]	YGYTHLSTGDLLRbSEVSSGSAR	44	Helix (39–48)	100
TAGL3	Transgelin-3	Na et al. 2015 [69]	RbGFSEEQLR	160	–	100
SYT7	Synaptotagmin-7	Chakrabarti et al. 2003 [70]	YKNSLETVGTPDSGRbGR	63	–	100
STMN1	Stathmin	Bsibsi et al. 2010 [71]	RbASGQAFELILSPR	14	–	71
P2RX7	P2X purinoceptor 7	Lister et al. 2007 [52]	LPLALHDTPPIPGQPEEIQLLRbK	463	–	57
HSP90AA1	Heat shock protein HSP 90-alpha	Tukaj et al. 2016 [72]	GVVDSEDLPLNISRbEMLQQSK	400	–	40
NEUM	Neuromodulin	Hung et al. 2016 [73]	IQASFRbGHITR	43	–	100
MBP	Myelin basic protein	Zierath et al. 2015 [74]	FGYGGRbASDYK	64	–	45
			SHGRbTQDENPVVHFF	213c	EAE (179–222)	41
			HGFLPRbHRDTGILDSIGR	165	–	32
			FFGGDRbGAPKR	183c	EAE (179–222)	75
			YLATASTMDHARbHG	159	–	58
			FSWGAEGQRPGFGYGGRbASDYKSAHK	264	–	45
CTTN	Src substrate cortactin	Labrador-Horrillo et al. 2014 [75]	HCSQVDSVRbGFGGK	119	–	100

^bIndicates the citrulline residues in the identified peptides

^cIndicates the MBP citrulline residues in mice that were identified in the protein homolog region that induces experimental autoimmune encephalomyelitis (EAE)

^aIndicates the stoichiometric ratio (percentage of occurrence) of Cit from the total peptides identified that contain the Arg site in the protein (unmodified + modified)