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. 2017 Sep 2;36:116. doi: 10.1186/s13046-017-0589-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — MCC950 inhibits NLRP3 inflammasome-induced CSCs formation in Tgfbr1/Pten 2cKO mice. a Western blot analysis showed that the expression of NLRP3 inflammasome and CSCs makers BMI1, ALDH1 and CD44 were downregulated in the MCC950 treatment group than in the control group. b Immunohistochemical staining of NLRP3 inflammasome, BMI1, ALDH1 and CD44 in Tgfbr1/Pten conditional knockout mice after MCC950 treatment. Scale bars = 50 μm. c Quantitative analysis showed that the expression of NLRP3 inflammasome, BMI1, ALDH1 and CD44 was significantly reduced in the MCC950 treatment group than in the control group (Mean ± SEM, **P < 0.01; *P < 0.05)