Fig. 4.

Less retina sprouting angiogenesis in Apln-CreERT:mT/mG mice when induced at late postnatal time and more at hypoxia condition. a-b The GFP-labeled retina sprouting angiogenesis decreases gradually in Apln-CreERT:mT/mG mice following tamoxifen administration from P5-P7 (a) with quantification results (b). c-d Apln-CreERT:mT/mG mice exhibit more abundant GFP-labeled retina sprouting angiogenesis at hypoxia than normoxia condition (c) with quantification results (d). Data quantification was mean ± S.E.M (n = 3). All data were analyzed using Student’s t-test unless otherwise noted. n.s., not significant; *, P < 0.05; **, P < 0.01. Scale bars: a, b, 1000 μm