Table 1.
Baseline characteristics of the study population
| OVERT ARVD/C (N = 39) |
Preclinical ARVD/C (n = 40) | Controls (n = 31) |
|
|---|---|---|---|
| Female (%) | 22 (56) | 18 (45) | 14 (45) |
| Age (yrs) | 32.3 ± 13.5 | 31.3 ± 18.1 | 37.2 ± 14.9 |
| Global CMR parameters | |||
| RV EDV/BSA (mL/m2) | 88.3 ± 25.6a | 68.4 ± 14.4 | 69.7 ± 12.9 |
| RV ESV/BSA (mL/m2) | 47.4 ± 24.9a | 31.1 ± 9.8 | 30.0 ± 8.6 |
| RV EF (%) | 48.3 ± 11.7a | 54.9 ± 9.6 | 56.9 ± 9.7 |
| LV EDV/BSA (mL/m2) | 77.4 ± 12.1 | 69.1 ± 12.9 | 73.5 ± 9.6 |
| LV ESV/BSA (mL/m2) | 30.6 ± 9.5 | 25.2 ± 7.0 | 30.9 ± 15.1 |
| LV EF (%) | 62.7 ± 6.3 | 63.2 ± 11.7 | 58.9 ± 13.3 |
| Clinical Phenotype | |||
| Repolarization criteria | - | ||
| Major | 36 (93) | 1 (3) | |
| Minor | 22 (54) | 19 (48) | |
| Depolarization criteria | - | ||
| Major | 3 (8) | 0 (0) | |
| Minor | 19 (49) | 18 (45) | |
| Arrhythmia criteria | - | ||
| Major | 7 (18) | 0 (0) | |
| Minor | 26 (67) | 4 (10) | |
| Structural criteria | - | ||
| Major | 16 (41) | 0 (0) | |
| Minor | 7 (18) | 0 (0) | |
| TFC fulfillment: number of criteria (median) | 6 (IQR 5–7) | 2 (IQR 2–3) | - |
Abbreviations: ARVD/C Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, BSA Body Surface Area, EDV End-Diastolic Volume, EF Ejection Fraction, ESV End-Systolic Volume, TFC Task Force Criteria, N number of subjects
a Statistical significant difference compared to control subjects