Table 3.
Brain Areas Showing Ayahuasca-Induced Statistically Significant Changes in Seed-to-Voxel Resting-State Functional Connectivity for the dACC Seed at MNI Coordinates (5, 14, 42) and the srACC Seed at (0, 15, 30)
| Brain Area | BA | MNI (x, y, z) | Number of voxels | Maximum t value |
|---|---|---|---|---|
| dAAC seed (5, 14, 42) | ||||
| Areas showing increased connectivity | ||||
| Precuneus, posterior cingulate cortex | 31 | (-6, -42, 40) | 864 | 3.76 |
| Areas showing decreased connectivity | ||||
| Cuneus (occipital lobe) | 18/19 | (28, -82, 0) | 739 | 5.56 |
| srACC seed (0, 15, 30) | ||||
| Areas showing increased connectivity | ||||
| Parahippocampal gyrus, hippocampus, amygdala (R) | 35/28 | (24, -18, -24) | 660 | 6.04 |
| Angular gyrus, inferior parietal lobule (L) | 7/40/39 | (-32, -74, 54) | 633 | 6.02 |
| Precuneus, posterior cingulate cortex (L&R) | 31/7 | (14, -54, 28) | 1436 | 5.02 |
| Areas showing decreased connectivity | ||||
| Cuneus (occipital lobe) | 18/19 | (-2, -94, 6) | 790 | 4.76 |
Abbreviations: dACC, dorsal anterior cingulate cortex; srACC, superior rostral anterior cingulate cortex.
Data shows results for the pair-wise comparison (post- vs. pre-intake) corrected for multiple comparisons at the cluster level (FWE < 0.05, z > 2.5, 20 contiguous voxels). The MNI coordinates indicate the location of the voxel with the maximum t value.