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. 2017 May 31;20(9):758–768. doi: 10.1093/ijnp/pyx041

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Published by Oxford University Press on behalf of CINP 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

This Open Access article contains public sector information licensed under the Open Government Licence v2.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/2/).

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Figure 5. — Effects of adolescent alcohol exposure on acetylated histone H3K9/14 occupancy at pro-opiomelanocortin (Pomc) and melanocortin 4 receptor (Mc4r) gene promoters at 2 locations as shown in upper panel. Rats exposed to adolescent intermittent ethanol (AIE) and saline (AIS) were used to measure for H3K9/14 occupancy at the Mc4r promoter region in the amygdala and at both the Mc4r and Pomc promoter regions in the hypothalamus in adulthood by chromatin immunoprecipitation (ChIP) assay. Values are represented as the mean ± SEM of the fold change derived from the AIS adult rats (*P<.05, **P<.01, ***P<.001 significantly different from control AIS rats, Student’s t test, n = 4–6 [amygdala], n = 7 [hypothalamus]).