Figure 1.

Changes in the intratumoral distribution of oxygen bubbles over time after injection of sodium hyaluronate with or without H₂O₂. The mean values below the images represent the percentage of oxygen bubbles on CT slices of the maximum tumor size (three mice per group). Compared with the groups receiving H₂O₂ immediately (1 min) before scanning, all the other groups had significantly smaller proportions of oxygen bubbles (P < 0.05). In the mice receiving 0.5‐mL injection, there were no differences in the proportion of oxygen bubbles among the 15‐min, 30‐min, and 60‐min groups (15 min vs 30 min: P = 0.18; 15 min vs 60 min: P = 0.057; 30 min vs 60 min: P = 0.65).