Figure 1.
l‐OHP formulations exhibited antitumor effect without systemic toxicity in C26 tumor‐bearing immunocompetent BALB/c mice. C26 cells (2 × 106 cells) were inoculated subcutaneously into BALB/c mice. On days 0, 7 and 14, C26 tumor‐bearing mice received three intravenous injections of either l‐OHP (Free l‐OHP) or l‐OHP‐containing PEGylated liposome (Lipo l‐OHP) at a dose of 8.3 mg l‐OHP/kg. Non‐treated mice served as the control. (a) Tumor volume. (b) Body weight. (c) Number of splenocytes. Each value represents the mean ± SD (n = 5). *P < 0.05.