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l‐OHP formulations exhibited no antitumor effect in C26 tumor‐bearing immunodeficient BALB/c nude mice. C26 cells (2 × 106 cells) were inoculated subcutaneously into BALB/c nude mice. On days 0, 7 and 14, C26 tumor‐bearing mice received three intravenous injections of either Free l‐OHP or Liposomal l‐OHP at a dose of 8.3 mg l‐OHP/kg. Non‐treated mice served as the control. (a) Tumor volume. (b) Body weight. Each value represents the mean ± SD (n = 5). *P < 0.05.
