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. 2017 Jul 14;108(9):1864–1869. doi: 10.1111/cas.13305

Figure 3.

Figure 3

l‐OHP formulations eliminated immunosuppressive cell components from tumors. On days 0, 7 and 14, C26 tumor‐bearing immunocompetent BALB/c mice received three intravenous injections of either Free l‐OHP or Liposomal l‐OHP. Non‐treated mice served as the control. On day 21, tumors were collected and tumor tissue suspensions were prepared. Those cells were stained with various antibodies before flow cytometry analysis. Cells were gated on size and expression of each marker. (a) The frequency of Treg (CD4+ CD25+), (b) MDSC (CD11b+ Gr‐1+) and (c) TAM (F4/80+ CD206+) in tumors. The percentage of each population was calculated by dividing each cell population number by the total cell number in tumor tissue. Each value represents the mean ± SD (n = 3). **P < 0.01.