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. 2017 Aug 12;108(9):1820–1827. doi: 10.1111/cas.13318

Figure 4.

Figure 4

Effect of VER155008 on full‐length androgen receptor (AR‐FL) and androgen receptor splice variant 7 (AR‐V7) transcription level. (a) LNCaP95 prostate cancer cells were treated with DMSO or VER155008 (VER; 25 μM) for 24 h. The AR‐FL and AR‐V7 transcripts were examined using quantitative RT‐PCR. The mRNA levels were normalized to that of HSPA8 as internal standard, and the values of relative target expressions in vehicle‐treated cells were set to 1. Asterisks indicate statistical significance. *P < 0.05, **P < 0.01 versus vehicle by unpaired t‐test; values are SEM (n = 3). (b) LNCaP95 cells were treated with VER155008 (25 μM) for 48 h. Protein extracts (15 μg) were subjected to Western blot analysis. CREB, cAMP response element binding protein; Sp1, specificity protein 1.