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Predominance of gain‐of‐function mutations in the TCR/NF‐κB pathway. Frequent gain‐of‐function alterations in TCR/NF‐κB and other related pathways, as well as loss‐of‐function alterations of their negative regulators are observed in adult T‐cell leukemia/lymphoma (ATL). The major driver alterations are summarized with their frequencies. Amp, amplification; Del, deletion; Mut, mutation.
