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. Author manuscript; available in PMC: 2018 May 25.
Published in final edited form as: Oncogene. 2016 Dec 19;36(21):3015–3024. doi: 10.1038/onc.2016.455

Figure 6. Biological screen to identify small molecules that can enhance activation of the proximal PAX2 promoter in MOE cells.

Figure 6

A) Top 12 compounds that consistently activated PAX2 promoter activity upon re-testing by primary biological assay. Luteolin increased PAX2 B) mRNA and protein in MOE cells compared to DMSO. Functionally, luteolin significantly decreased C) proliferation (day 3) and migration (hour 24) in MOE cells.