Figure 5. p53 deficient mOS cells are sensitive to p53-induced translation stress.
(A) Proliferation of p53/Rb-null and p53-null/Rb-wt expressing a dox-inducible p53 following treatment with vehicle control or doxycycline (B) Western blot analysis of the indicated proteins in vehicle control or dox-treated p53/Rb-null and p53-null/Rb-wt cells that express a dox-inducible p53. “fl” indicates full-length protein, whereas “cl” denotes cleaved protein.