FIG. 3.

Simulated MTR_asym, APT^*, MTR_double,vdc, AREX, and AREX_double,vdc as a function of T₁ (a), T₂ (b), f_m (c), f_s (e), and k_sw (f), respectively, with the symmetric-solid three-pool model (amide, symmetric semi-solid component, water), and as a function of f_m (d) with the asymmetric-solid three-pool model (amide, asymmetric semi-solid component, water). Note that AREX_double,vdc depends significantly only on the solute parameters f_s and k_sw, but not other tissue parameters, while all other APT imaging methods depend on several other tissue parameters such as T₁, T₂, and f_m.