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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Cancer Discov. 2017 Jun 15;7(9):1018–1029. doi: 10.1158/2159-8290.CD-17-0613

Figure 2. Genomic Landscape of PCNSL.

Figure 2

A, Shown are mutation frequencies in PCNSLs (n=177), grouped into genes with recurrent somatic mutations, genes affected by aberrant somatic hypermutation, and genes meeting both criteria (see Supplementary Table S5). B, Relationship between PCNSL disease subtypes and mutations in BCR pathway members in PCNSL. The disease subtype is shown in the top row and was determined by IHC (GCB: germinal center B-cell like; non-GCB: non-germinal center B-cell like; T-cell). Missense mutations are displayed in green, in-frame mutations in grey, truncating mutations in black, amplifications in red and deletions in blue.