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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Mol Cancer Res. 2017 May 26;15(9):1197–1205. doi: 10.1158/1541-7786.MCR-17-0095

Figure 2. Properties of human-derived microDNA in serum of mice with human ovarian cancer xenografts.

Figure 2

(A) Length distribution of human microDNAs identified in the serum of two mice carrying xenografts of the human ovarian cancer SKOV3 cell line. (B) Median percent GC content of human-derived microDNAs and the genomic sequences of equal length upstream or downstream of the microDNA source locus are enriched relative to the average GC content of the human genome (dashed line). (C) Distribution of human-derived microDNA in the indicated genomic regions. (D) Percentage of microDNA with (black) or without (gray) 2- to 15-bp direct repeats flanking the microDNA sequence at the genomic source loci.