Table 4.
Associations between Cycle 1 to Cycle 2 Change in Neuropsychological Measures and Change in PiB Retention
| Striatum Change | Global Change | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| No Control for Age | Controlling for Age | No Control for Age | Controlling for Age | |||
|
| ||||||
| r | Estimate (SE) | t-value | r | Estimate (SE) | t-value | |
| Vineland | 0.01 | 0.85 (21.83) | 0.04 | −0.11 | −45.21 (31.81) | −1.42 |
| Free Recall | −0.24+ | 2.26 (3.64) | 0.62 | −0.21 | −2.49 (4.97) | −0.50 |
| Free and Cued Recall | −0.20 | 0.08 (3.33) | 0.02 | −0.34* | −10.93 (4.22) | −2.59** |
| Cued Recall Intrusions | 0.16 | 1.16 (2.43) | 0.48 | 0.35** | 10.27 (2.96) | 3.47*** |
| Block Design | −0.23 | −3.77 (4.81) | −0.78 | −0.32* | −14.30 (6.17) | −2.32* |
| Severe Impairment Battery | −0.05 | 0.63 (2.76) | 0.23 | −0.14 | −3.70 (3.66) | −1.01 |
| Visual Attention Time | 0.02 | 4.18 (28.01) | 0.15 | −0.07 | 10.62 (39.26) | 0.27 |
| Visual Attention Accuracy | −0.07 | 1.06 (2.61) | 0.41 | −0.10 | −2.28 (3.53) | 0.27 |
| Verbal Fluency Number | −0.22 | −7.51 (6.38) | −1.18 | −0.10 | −7.68 (8.62) | −0.89 |
| Verbal Fluency Repetition | −0.05 | 2.50 (2.51) | 1.00 | −0.04 | 5.68 (3.32) | 1.71+ |
| Purdue Pegboard - Single Hands | −0.36** | −1.80 (1.79) | −1.00 | −0.43** | −5.20 (2.34) | −2.23* |
| Purdue Pegboard - Both Hands | 0.05 | 1.29 (1.15) | 1.12 | −0.01 | 0.17 (1.60) | 0.10 |
| Story Recall Initial | −0.11 | −0.04 (1.41) | −0.03 | −0.03 | −0.01 (1.96) | −0.01 |
| Story Recall Initial – Delayed | −0.15 | −2.94 (2.54) | −1.16 | −0.13 | −3.64 (3.33) | −1.09 |
| Expressive One Word | −0.17 | −4.92 (8.43) | −0.58 | −0.19 | −8,85 (11.38) | −0.78 |
| PPVT age equivalent | 0.02 | −8.37 (18.68) | −0.45 | −0.03 | −17.11 (25.18) | −0.68 |
| Rivermead Picture Recognition | −0.22 | 0.21 (2.13) | 0.10 | −0.33* | −5.46 (2.65) | −2.06* |
| VMI | −0.19 | −3.40 (1.64) | −2.07* | −0.14 | −3.69 (2.25) | −1.64 |
| Cat Dog Switch Errors | 0.14 | −2.24 (2.57) | −0.87 | 0.13 | 1.74 (3.46) | 0.50 |
| Cat Dog Switch Time | 0.24+ | 17.40 (8.10) | 2.15* | 0.13 | 10.55 (11.32) | 0.93 |
| Corsi Forward | 0.18 | 9.04 (5.84) | 1.55 | 0.18 | 11.89 (7.81) | 1.52 |
| Corsi Backward | −0.10 | −4.31 (4.29) | −1.00 | −0.00 | −0.82 (5.24) | −0.16 |
| Digits Forward | 0.03 | 2.57 (4.80) | 0.54 | −0.13 | −3.73 (6.27) | −0.59 |
| Digits Backward | −0.02 | −5.07 (4.01) | −1.27 | 0.06 | −1.16 (5.20) | −0.22 |
Note.
+
= p < .10;
*
= p ≤ .05;
**
p ≤ .01;
***
p ≤ .001. As follow-up, analyses were re-run excluding individuals with floor level (i.e., lowest possible score) scores at Cycle 1 as these individuals would not be able to show decline. The pattern of significant results remained the same.