Figure 2.

Changes in cellular gene expression in chronically hepatitis B virus (HBV)–infected human liver tissue and in HBV-related hepatocellular carcinoma (HCC). Liver tissue samples from healthy HBV-naive subjects (healthy, n = 11), from chronically HBV-infected patients (HBV, n = 11) and patients who had developed HBV-related HCC (HBV/HCC, n = 13) were analyzed for expression of the cIAP2, Mn-SOD, IER3, TNFAIP8, CYP3A4, and IGFBP1 genes by real-time reverse transcription polymerase chain reaction. Each data point represents the expression level determined in a single sample. Mean expression level ± SD in each group and statistical significance (Student's t test) are given.