Table 2.

Gene Expression Profiling of HBV-Infected PHH Cultures

Samplea	Transcripts up-regulatedb	Transcripts down-regulatedb	Relative efficiency of HBV replication (%)c	HBeAg (ng/mL)d
PHH1	192	416	15	11.1
PHH2	894	1364	45	21.7
PHH3	511	349	30	14.95
Common regulated in all PHHs	40	17	—	—

^aPrimary human hepatocyte (PHH) prepared from different patients (1–3), RNA isolated on day 4 post–mock or hepatitis B virus (HBV) infection.

^bUp- or down-regulated transcripts in HBV-infected PHHs compared with mock-infected PHH, fold change ≥1.5.

^cRelative expression levels of HBV pregenomic RNA determined by real-time reverse transcription polymerase chain reaction on day 4 postinfection.

^dLevels of hepatitis B early antigen secreted into the culture medium on day 4 postinfection.