Table 1.
Rate of adolescent SI mice that show resistance to the single administration of S-fluoxetine (S-FLX), ganaxolone (GNX), BR351, BR297, and PEA.
Drug treatment | “Non-responders” Late SI mice (%) |
“Non-responders” Late SI mice (n) |
“Non-responders” Early SI mice (%) |
“Non-responders” Early SI mice (n) |
---|---|---|---|---|
S-FLX 0.375 mg S-FLX 0.75 mg S-FLX 1.5 mg GNX 10 mg BR351 1 mg BR351 2.5 mg BR351 5 mg BR297 0.3125 mg BR297 0.625 mg BR297 2.5 mg PEA 5 mg PEA 10 mg PEA 15 mg PEA 20 mg |
64.3% 23.1% 11.8% 15.4% 54.6% 40.0% 8.3% 18.2% 18.2% 0% 42.9% 0% 0% 0% |
9/14 3/13 2/17 2/13 6/11 4/10 1/12 2/11 2/11 0/12 3/7 0/7 0/7 0/7 |
64.3% 53.3% 22.2% 25.0% 50.0% 20.0% 13.3% 30.0% 21.4% 6.3% 53.9% 26.7% 0% 0% |
9/14 8/15 4/18 3/12 8/16 3/15 1/16 3/10 3/14 1/16 7/13 4/15 0/13 0/17 |