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. 2017 Aug 28;8:1020. doi: 10.3389/fimmu.2017.01020

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Copyright © 2017 Harms, Creer, Lorenzo-Arteaga, Ostlund and Sarvetnick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Splenic natural killer (NK) cells are reduced in abundance among interleukin (IL)-18BPKO mice. (A) Identification of splenic NK cells. Living, singlet events were selected from total splenocytes. After gating out debris, we selected lineage (CD3, CD19, Ly-6G), NK1.1⁺ events as NK cells. NK cell phenotype was confirmed with NKp46 labeling. Total splenocytes (B) were relatively similar between wild-type (WT) and IL-18BPKO mice, yet the proportion (C) and absolute number (D) of NK cells was significantly reduced among IL-18BPKO mice. Results from three unique experiments from six WT and eight IL-18BPKO mice. Bars represent median. Significance calculated with Mann–Whitney U test. **p < 0.01, ***p < 0.001, ns, not significant.