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. 2017 Aug 28;8:1020. doi: 10.3389/fimmu.2017.01020

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Copyright © 2017 Harms, Creer, Lorenzo-Arteaga, Ostlund and Sarvetnick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Similar to what we observed in the spleen, CD27⁺, CD11b⁻ bone marrow natural killer (NK) cells are increased in abundance while CD27⁻, CD11b⁺ bone marrow NK cells are reduced in abundance among interleukin (IL)-18BPKO mice. (A) Representative gating of CD27 versus CD11b on bone marrow NK cells. (B) CD27⁺, CD11b⁻ NK cells are increased in proportion and abundance in the bone marrow of IL-18BPKO mice, while (C) CD27⁻, CD11b⁺ NK cells are reduced in proportion and abundance. Results from three unique experiments from six WT and eight IL-18BPKO mice. Bars represent median. Significance calculated with Mann–Whitney U test. **p < 0.01, ***p < 0.001.