Table 3.
Positive Correlations Between DAT Availability in Patients and PANSS Scores
PANSS Item | Region | Cluster Level | Peak Level | |||||
---|---|---|---|---|---|---|---|---|
Cluster Size (Voxels) | P FWE Corrected | Peak Voxel | P Uncorrected | MNI Coordinates | ||||
t Value | x | y | z | |||||
P3 | L amygdala | 187 | .028 | 4.96 | 6.0 e-5 | −30 | 2 | −16 |
L hippocampus | 4.86 | 7.3 e-5 | −26 | −14 | −16 | |||
P5 | L pallidum/putamen | 148 | .046 | 4.38 | 2.0 e-4 | −20 | 0 | 0 |
P6 | L putamen (dorsal) | 2297 | <.0001 | 8.07 | 1.6 e-7* | −24 | −4 | 18 |
L putamen | 6.49 | 2.8 e-6* | −20 | 12 | 4 | |||
L subcallosal | 5.67 | 1.4 e-5* | −10 | 20 | −12 | |||
L pallidum | 5.31 | 2.9 e-5 | −12 | 4 | 2 | |||
R putamen (dorsal) | 2273 | <.0001 | 6.99 | 1.1 e-6* | 24 | −6 | 14 | |
R putamen | 6.02 | 6.9 e-6* | 32 | 14 | −4 | |||
R subcallosal | 5.89 | 2.5 e-5 | 14 | 22 | −12 | |||
G9 | R amygdala | 471 | .001 | 4.90 | 6.7 e-5 | 22 | −2 | −14 |
R hippocampus | 4.72 | 9.9 e-5 | 26 | −16 | −14 | |||
Olfactory cortex/anterior cingulate | 4.29 | 2.5 e-4 | 4 | 8 | −12 |
Height threshold P < .001 and extent threshold at P < .05 family wise error (FWE) corrected. L, left; R, right; MNI, Montreal Neurological Institute; VTA, ventral tegmental area; P3, hallucinations; P5, grandiosity; P6, suspiciousness/persecution; G9, unusual thought content.
aHeight threshold P < .05 FWE corrected.