Table 4.
Comparing Rates of Psychiatric Comorbidities and Level of Intellectual and Global Functioning in 22q11.2 Deletion Syndrome Participants With Subthreshold Psychotic Symptoms Vs Those Without
| Variables | No. (%)a | ||||
|---|---|---|---|---|---|
| Positive Subthreshold Psychotic Symptoms | Non-Subthreshold Psychotic Symptoms | t/χ2 | P | ES | |
| Any anxiety disorder | 125/227 (55.1) | 161/459 (35.1) | 25.54 | <.001 | .19 |
| Any mood disorder | 45/227 (19.8) | 65/459 (14.2) | 3.66 | .06 | .07 |
| Any ADHD | 89/218 (40.8) | 153/447 (34.2) | 2.75 | .10 | .06 |
| Any disruptive disorder | 7/218 (3.1) | 15/447 (3.3) | .01 | .92 | .001 |
| Substance-related disorder | 5/188 (2.6) | 7/375 (1.9) | .38 | .54 | .02 |
| FSIQ, mean ± SD | 74.4 ± 12.1 | 78.2 ± 13.3 | 3.16 | <.01 | .30 |
| VIQ, mean ± SD | 78.8 ± 12.7 | 81.2 ± 13.7 | 1.86 | .06 | .18 |
| GAF, mean ± SD | 57.4 ± 12.1 | 69.4 ± 46.6 | 3.83 | <.001 | .35 |
| Negative/disorganized Subthreshold Symptoms | Non-Subthreshold Symptoms | t/χ 2 | P | ES | |
|---|---|---|---|---|---|
| Any anxiety disorder | 61/140 (43.6) | 80/270 (29.6) | 7.64 | <.01 | .14 |
| Any mood disorder | 26/140 (18.6) | 35/270 (12.9) | 2.29 | .13 | .07 |
| Any ADHD | 59/134 (44.0) | 73/264 (27.3) | 10.75 | <.001 | 16 |
| Any disruptive disorder | 4/134 (2.9) | 6/264 (2.3) | .18 | .67 | .02 |
| Substance-related disorder | 3/119 (2.5) | 4/255 (1.5) | .41 | .52 | .03 |
| FSIQ, mean ± SD | 75.8 ± 12.3 | 80.7 ± 12.8 | 3.13 | <.01 | .39 |
| VIQ, mean ± SD | 78.3 ± 12.7 | 83.3 ± 13.7 | 2.92 | <.01 | .38 |
| GAF, mean ± SD | 60.4 ± 14.8 | 71.4 ± 11.3 | 7.63 | <.001 | .84 |
Note: ADHD, attention deficit hyperactivity disorder; FSIQ, full-scale IQ; VIQ, verbal IQ; GAF, global assessment of functioning; ES, effect size (Eta-squared [η2] for chi-square; Cohen’s d for t-test).
a
% of valid cases (excluding those with missing data); Statistical analysis was conducted with Chi-square tests (χ2) in case of rates comparison, and with independent t-test in case of means comparison; Two categories are tabulated: positive subthreshold and then separately the negative/disorganized subthreshold symptoms.