FIGURE 2.

Topographic effects of HRS treatment on the field potentials of MNU administered rats. (A) Representative field potential waveforms of the examined eyes. The field potentials of the untreated group were substantially ruined by MNU administration and no consolidated waveform was found; conversely, the field potential waveforms of the IV and IP treated group were preserved efficiently. (B) The mean amplitudes of field potentials in the untreated group was remarkably smaller than normal controls (P < 0.01). The mean amplitude of field potentials in the IV and IP treated group were significantly larger than the untreated group (P < 0.01). The mean amplitude of field potentials in the IP treated group was smaller than the IV treated group (P < 0.05). The field potentials in peripheral region of IP treated group retained larger amplitudes than the central and mid-peripheral region (P < 0.01); the mean amplitude of field potentials in the mid-peripheral region was significantly smaller than the peripheral region (P < 0.01). The field potential responses in IV treated group were much more uniformly distributed, except for the mean amplitude in the central region was slightly smaller than the peripheral region (P < 0.05) (All the values were presented as mean ± SD; ^∗P < 0.05, ^#P < 0.01 for differences compared between the animal groups).