Table 2.
Association of S. aureus virulence factors with community-acquired skin and soft tissue infection (SSTI).
| Virulence factor (n) | SSTI (n = 57), | Other infections | OR (95% CI) | P-value |
|---|---|---|---|---|
| n (%) | (n = 29)a, n (%) | |||
| agrIV (9) | 8 (14%) | 1 (4%) | 4.6 (0.5–38.5) | 0.2 |
| agr deficiency (6) | 5 (9%) | 1 (4%) | 2.7 (0.3–24.2) | 0.4 |
| seb (10) | 8 (14%) | 2 (7%) | 2.2 (0.4–11.1) | 0.3 |
| lukF-PV/lukS-PV (37) | 31 (54%) | 6 (21%) | 4.6 (1.6–12.9) | 0.004 |
| hlb (23) | 20 (35%) | 3 (10%) | 4.7 (1.3–17.4) | 0.02 |
| adsA (84) | 56 (98%) | 28 (97%) | 2 (0.1–33.2) | 0.6 |
| tst1 (25) | 16 (28%) | 9 (31%) | 0.9 (0.3–2.3) | 0.8 |
Only virulence factors were included in this multivariate analysis if they showed at least weak evidence for an association with infection (p ≤ 0.2 and OR ≥ 1), see Supplementary Table S2. a Including urinary tract infection (n = 10), ENT infection (n = 7), bloodstream (n = 4), respiratory tract infection (n = 2), amnionitis, eye infection, foreign body infection, joint infection, peritonitis, prostatitis (each n = 1).