Table 2.
Univariate analysis for ICU- and hospital survival
| Alive at ICU Discharge | Alive at Hospital Discharge | ||||||
|---|---|---|---|---|---|---|---|
| Variable | Category | No (%) | Yes (%) | p | No (%) | Yes (%) | p |
| Stem cells | BM | 1 (8) | 11 (92) | 0.007 | 8 (67) | 4 (33) | 0.07 |
| PB | 40 (33) | 81 (67) | 59 (49) | 62 (51) | |||
| CB | 16 (57) | 12 (43) | 20 (71) | 8 (29) | |||
| TBI | N | 29 (29) | 70 (71) | 0.04 | 49 (49.5) | 50 (50.5) | 0.19 |
| Y | 28 (45) | 34 (55) | 38 (61) | 24 (39) | |||
| Renal replacement | N | 31 (27) | 85 (73) | <0.001 | 50 (43) | 66 (57) | <0.001 |
| Y | 26 (58) | 19 (42) | 37 (82) | 8 (18) | |||
| Vasopressors | N | 10 (12) | 73 (88) | <0.001 | 26 (31) | 57 (69) | <0.001 |
| Y | 47 (60) | 31 (40) | 61 (78) | 17 (22) | |||
| Vasopressors at transfer | N | 35 (30) | 83 (70) | 0.02 | 56 (47.5) | 62 (52.5) | <0.001 |
| Y | 22 (51) | 21 (49) | 31 (72) | 12 (28) | |||
| MV | N | 2 (3) | 57 (97) | <0.001 | 11 (19) | 48 (81) | <0.001 |
| Y | 55 (54) | 47 (46) | 76 (74.5) | 26 (25.5) | |||
| MV at transfer | N | 24 (26) | 68 (74) | 0.005 | 39 (42) | 53 (58) | <0.001 |
| Y | 33 (48) | 36 (52) | 48 (70) | 21 (30) | |||
| Gram positive bacteremia | N | 32 (29) | 77 (71) | 0.02 | 52 (48) | 57 (52) | 0.03 |
| Y | 25 (48) | 27 (52) | 35 (67) | 17 (33) | |||
| Primary organ failure | Circulatory | 5 (13) | 33 (87) | 0.002 | 9 (24) | 29 (76) | <0.001 |
| Respiratory | 48 (44) | 62 (56) | 72 (65.5) | 38 (34.5) | |||
| Other | 4 (31) | 9 (69) | 6 (46) | 7 (54) | |||
| Number of organ failures | 1 | 16 (21) | 59 (79) | 0.002 | 29 (39) | 46 (61) | 0.004 |
| 2 | 25 (47) | 28 (53) | 36 (68) | 17 (32) | |||
| 3+ | 16 (48.5) | 17 (51.5) | 22 (67) | 11 (33) | |||
| Sepsis | N | 28 (28) | 71 (72) | 0.02 | 43 (43) | 56 (57) | <0.001 |
| Y | 29 (47) | 33 (53) | 44 (71) | 18 (29) | |||
| Year group | 2002–2007 | 27 (43.5) | 35 (56.5) | 0.09 | 43 (69) | 19 (31) | 0.002 |
| 2008–2013 | 30 (30.3) | 69 (69.7) | 44 (44) | 55 (56) | |||
| Days post aHSCT to ICU | Median (IQR) | 13 (5 – 33) | 9.5 (5 – 17.5) | 0.13 | 11 (6 – 31) | 8.5 (3 – 18) | 0.03 |
| MPM score | Median (IQR) | 43.3 (26.8 – 57.4) | 30.1 (19.8 – 51.8) | 0.03 | 41.5 (26.3 – 58.3) | 26.5 (17.5 – 46.1) | 0.003 |
| Tbili at trans | Median (IQR) | 1.5 (0.7–2.8) | 0.8 (0.5–1.5) | 0.002 | 1.2 (0.7–2.4) | 0.7 (0.4–1.3) | <0.001 |
| Cr at trans | Median (IQR) | 1.6 (1.2–3.1) | 1.3 (0.9–2.0) | 0.01 | 1.6 (1.2–2.4) | 1.2 (0.9–1.8) | 0.002 |
| # PRBCs in ICU | Median (IQR) | 7 (4–11) | 3 (1–5) | <0.001 | 5 (3–11) | 2.5 (1–4) | <0.001 |
BM=bone marrow, CB=cord blood, Cr = Creatinine, IQR = interquartile range, MPM = Mortality Probability Model-II, MV = mechanical ventilation, PB=peripheral blood,TBI = total body irradiation, Tbili = total bilirubin, trans = ICU-transfer, PRBCs = packed red blood cells