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. Author manuscript; available in PMC: 2017 Sep 3.
Published in final edited form as: Gene Ther. 2015 Dec 10;23(2):231–236. doi: 10.1038/gt.2015.103

Figure 2. AAV genome (mCherry DNA) was detected in the spinal cord after cortical AAV1 injection, which was reduced by a prior pyramidotomy.

Figure 2

(a) Schematic representation of the rat CST and a heatmap showing the amount of mCherry DNA detected in each hemisphere’s cortex and each half of the spinal cord of uninjured or pyramidotomised rats. Numbers represent the average concentration of mCherry DNA relative to GAPDH. (b) Quantification of the relative level of mCherry DNA in the left (uninjected) and right (injected) cortex of uninjured or pyramidotomised rats. A significantly higher level of mCherry DNA was detected in the injected cortex and no difference between uninjured and pyramidotomised animals was observed. (c) Quantification of the relative level of mCherry DNA in the contralateral and ipsilateral spinal cord of uninjured or pyramidotomised rats. A significantly increased level of mCherry DNA was detected in the contralateral spinal cord of uninjured animals, which was significantly reduced by a prior pyramidotomy.