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There are the extrinsic (receptor-mediated, red) and intrinsic (mitochondria-driven, blue) apoptosis pathways as opposed to the survival proteins such as the PI3K/Akt signaling circuitry (yellow). Other signaling loops (green) and executioner caspase (black), are activated in both extrinsic and intrinsic pathways; inter-talk between pathways (arrows); phosphorylation (P). From reference 14 - Lee, SC, Pervaiz, S. Int J Biochem Cell Biol 2007;39(3):497-504.
