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. Author manuscript; available in PMC: 2017 Sep 3.
Published in final edited form as: Adv Drug Deliv Rev. 2017 Apr 25;114:33–42. doi: 10.1016/j.addr.2017.04.011

Figure 3.

Figure 3

Retention in skin is size dependent and remains relatively unchanged by tumor growth and progression. (A) Total exposure (AUC calculated from measured tissue concentrations) of tracers injected into naïve skin of C57Bl6 mice increases with increasing hydrodynamic size. * indicates significant for 5–12 vs 25, 50, and 500 nm tracers by one-way ANOVA and posthoc Fisher’s LSD tests. (B) Tracer retention and resulting exposure within the skin or melanoma site of injection is relatively unchanged by tumor growth. (C) Micro-computed tomography 3D reconstructions of the remodeling tumor blood vasculature in naïve skin and B16F10 melanomas. Day refers to day post B16F10 implant. Reproduced from REF 55 (B,C) and REF 56 (A) with permission.