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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Mol Immunol. 2017 Jun 7;89:73–83. doi: 10.1016/j.molimm.2017.05.025

Table 1.

Main features of C1q receptors

Names
(CD number)
Family		 Cellular
expression		 Ectodomain
composition		 C1q region
recognized		 Main protein
ligands
/partners		 C1q–mediated biological
response
gC1qR, C1qBP, p33, p32 Mitochondrial protein “doughnut-like” trimer gC1q DC-SIGN, CRT β1 integrin Regulation of DC differentiation (trimolecular complex with DC-SIGN)
cC1qR, calreticulin, CRT ER lectin-like chaperone Lectin-like + “arm” cC1q MBL, ficolins, LRP1, CD59 Eat-me signal for apoptotic cells phagocytosis
gC1q
CR1 (CD35) Regulator of complement activation Erythrocytes, leukocytes, DCs 4 long homologous repeats of CCP modules cC1q C3b, C4b MBL, ficolins Possible role in the clearance of immune complexes
LRP1,α2M receptor (CD91) LDL receptor MФs, DCs, nonprofessional phagocytes 4 clusters of LA, WTD and EGF-like modules cC1q Lipoproteins, ECM proteins, CRT, CR3, protease-inhibitor complexes Uptake of apoptotic cells
gC1q
α2β1 β1 integrin leukocytes, platelets α-β heterodimer cC1q Collagen, laminin MBL, SP-A, CRT Activation of peritoneal mast cells
CR3, Mac1, αMβ2 (CD11bCD18) β2 integrin Specific MФ populations, DCs α-β heterodimer ? iC3b, sRAGE, LRP1, collagen Apoptotic cells clearance (trimolecular complex with RAGE)
SREC-I, SCARF1, SR-F1 Scavenger receptor Macrophages, DCs, endothelial cells 7 EGF-like modules ? oxLDL, HSP, CRT, SRF-2 ectodomain Apoptotic cells clearance
Megf10, SR-F3 Scavenger receptor Astrocytes, myosatellite cells EMI + 15 EGF-like modules ? amyloid-β peptide (Aβ42) Apoptotic cells clearance by astrocytes
RAGE, SR-J Ig superfamily receptor Leukocytes, DCs, endothelial cells, neurons 3 IgG-like modules (V-C1-C2) gC1q HMGB1, AGE, PS, CR3, Apoptotic cells clearance (trimolecular complex with CR3) Differentiation of monocytes to M2-like macrophages (tetramolecular complex with LAIR-1 and HMGB1)
LAIR-1 (CD305) Inhibitory Ig-like immune receptor Myeloid and lymphoid immune cells Ig-like module (C2) cC1q MBL, SP-D, collagens) Restriction of DC differentiation and activation Differentiation of monocytes to anti-inflammatory M2-like MФs (tetramolecular complex with RAGE and HMGB1)
Siglec-3 (CD33) Inhibitory Ig-like immune receptor Myeloid immune cells 2 IgG-like modules (V-C2) gC1q CD14 Restriction of DC differentiation and activation (trimolecular complex with LAIR-1)
DC-SIGN (CD209) C-type lectin receptor Most immune cells, Macrophages, DCs, PMNs Tetramer; neck + C-lectin domain gC1q ICAM-3, gC1qR Regulation of DC differentiation (trimolecular complex with gC1qR)