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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Trends Cardiovasc Med. 2017 May 17;27(7):451–459. doi: 10.1016/j.tcm.2017.05.005

Figure 10. Effects of lidocaine on APD after acute and chronic dofetilide superfusion in vitro.

Figure 10

After 3 h of adaptation in control solution, endocardial strips were superfused starting at 0 min with control solution containing 0.2 μM dofetilide, 100 μM moxifloxacin (Mox) or vehicle. Lidocaine (Lido; 20 μM for 20 min) was added to the superfusate at 30 min for dofetilide and 60 min for moxifloxacin, and again at 390 min. APD90 was measured periodically throughout the experiment. The largest effect of lidocaine is seen at 390 min in the dofetilide-treated sample. From (18).