. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Mol Aspects Med. 2017 Mar 3;58:1–11. doi: 10.1016/j.mam.2017.03.001

Table 1.

Specialized Pro-resolving Mediators (SPM): Anti-Phlogistic Pro-Resolving Actions

SPM defining bioactions
Temporal stereospecific biosynthesis with leukocyte exudate traffic Cessation of PMN infiltration; stop signals to limit further PMN recruitment and stop PMN-mediated tissue damage Enhance macrophage phagocytosis of apoptotic PMN, cellular debris and bacteria killing SPM have broad anti-inflammatory and pro-resolving actions Actions at both transcriptional and translational level, miR SPM act via specific receptors in pico to nanomolar range in stereoselective fashion Shorten time to resolution and activate endogenous resolution programs

SPM defining bioactions

Temporal stereospecific biosynthesis with leukocyte exudate traffic
Cessation of PMN infiltration; stop signals to limit further PMN recruitment and stop PMN-mediated tissue damage
Enhance macrophage phagocytosis of apoptotic PMN, cellular debris and bacteria killing
SPM have broad anti-inflammatory and pro-resolving actions
Actions at both transcriptional and translational level, miR
SPM act via specific receptors in pico to nanomolar range in stereoselective fashion
Shorten time to resolution and activate endogenous resolution programs