. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Mol Aspects Med. 2017 Mar 3;58:1–11. doi: 10.1016/j.mam.2017.03.001

Table 2.

SPM Shorten Resolution of Infections, Increase Survival and Outcomes in Murine Infection & Disease Models

SPM	Increase Survival	Disease	Shorten resolution intervals R_i	Reference
LXA₄	+	Bacterial infections		(Walker et al., 2011)
15-epi-LXA₄	+	Lung injury		(El Kebir et al., 2009)
RvE1	+	Colitis	+	(Arita et al., 2005)
	+	Candida yeast	+	(Haas-Stapleton et al., 2007)
	+	Acid-induced lung injury	+	(Levy and Serhan, 2014)
RvD5, PD1	+	E. coli infection	+	(Chiang et al., 2012)
RvD1, RvD5, PD1	+	Acute lung injury	+	(Wang et al., 2011)
RvD2	+	Cecal ligation and puncture sepsis	+	(Chiang et al., 2017; Spite et al., 2009)
RvD2	+	Burn wound sepsis	+	(Bohr et al., 2013)
RvD2 RvD3 RvD4 MCTRs	+ +	Burn wound sepsis Aging mice, peritonitis Skin Inflammation peritonitis, organ protection	+ + + +	(Bohr et al., 2013) (Arnardottir et al., 2014) (Winkler et al., 2016) (Dalli et al., 2014)