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Cytokine levels in brain homogenates after cardiopulmonary bypass/deep hypothermic circulatory arrest by treatment group. ELISA assays revealed time-dependent reductions in brain levels of TNFα (A) and myeloperoxidase (B) in ANXA1sp-treated rats, with significant effects at 6 and 24 h post reperfusion. Data are presented as mean ± SD (n = 3–5 rats/group). *P < 0.05, **P < 0.01 compared to vehicle controls, analyzed with unpaired t test.
