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. 2017 Aug 30;8:1050. doi: 10.3389/fimmu.2017.01050

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Copyright © 2017 Zhang, Ma, Shah, Mackensen, Lo, Mathew, Podgoreanu and Terrando.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circulating cytokine levels after cardiopulmonary bypass/deep hypothermic circulatory arrest by treatment group. ELISA assays of plasma levels of TNFα (A), myeloperoxidase (MPO) (B), and IL-6 (C) showed that time-dependent effects were noted in TNFα and MPO levels, with significant reduction in ANXA1sp rats by 24 h post reperfusion. IL-6 levels were significantly reduced in ANXA1sp-treated rats as early as 3 h post reperfusion. Data are presented as mean ± SD (n = 3–5 rats/group). *P < 0.05, **P < 0.01 compared to vehicle controls, analyzed with unpaired t test.