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. 2017 Aug 30;8:1050. doi: 10.3389/fimmu.2017.01050

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Copyright © 2017 Zhang, Ma, Shah, Mackensen, Lo, Mathew, Podgoreanu and Terrando.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neurocognitive outcomes after cardiopulmonary bypass/deep hypothermic circulatory arrest and ANXA1sp or vehicle treatment. (A) Neurologic scores were assessed on day 3 and day 7 post operation. Sensory-motor functions were significantly improved at both time points in ANXA1sp-treated rats. (B) Morris water maze testing was performed daily from day 3 through day 7 post operation. Learning abilities were significantly improved in ANXA1sp rats on day 3 post operation. Data are presented as mean ± SD (n = 10 rats/group). *P < 0.003, **P < 0.01, ***P < 0.001 compared to vehicle controls. Mann–Whitney U test was applied for the neurological score comparisons at each recovery interval. Repeated measures ANOVA with Fisher’s least significance difference post hoc test was used for Morris water maze analysis.