Table 1.
Intraoperative physiologic data.
| Parameter | Group | Pre-CPB | 30 min CPB | 60 min DHCA | 10 min Reperfusion | End of CPB | 120 min P-CPB |
|---|---|---|---|---|---|---|---|
| MAP (mmHg) | Vehicle | 70 (7) | 30 (4) | – | 72 (25) | 88 (11) | 88 (6) |
| ANXA1sp | 66 (7) | 29 (4) | – | 49 (12) | 78 (22) | 81 (17) | |
| Temp. (°C) | Vehicle | 34.1 (0.8) | 19.3 (0.6) | 15.0 (0.1) | 21.9 (3.0) | 33.2 (0.6) | 36.0 (0.8) |
| ANXA1sp | 34.2 (0.3) | 19.1 (0.5) | 15.0 (0.1) | 22.0 (2.3) | 33.8 (0.5) | 36.4 (0.3) | |
| Glucose (mg/dL) | Vehicle | 124 (40) | – | 190 (44) | 143 (42) | ||
| ANXA1sp | 123 (46) | – | 170 (36) | 116 (38) | |||
| PH | Vehicle | 7.36 (0.08) | 7.46 (0.05) | – | 7.57 (0.08) | 7.28 (0.05) | 7.36 (0.03) |
| ANXA1sp | 7.38 (0.02) | 7.48 (0.09) | – | 7.51 (0.15) | 7.29 (0.02) | 7.40 (0.05) | |
| PO2 (mmHg) | Vehicle | 227 (46) | 516 (47) | – | 374 (69) | 245 (114) | 256 (71) |
| ANXA1sp | 253 (93) | 474 (77) | – | 257 (211) | 170 (138) | 247 (126) | |
| PCO2 (mmHg) | Vehicle | 53.2 (13.1) | 40.2 (3.8) | – | 28.6 (4.6) | 55.8 (8.7) | 52.0 (4.4) |
| ANXA1sp | 49.4 (5.1) | 38.6 (9.7) | – | 31.2 (12.0) | 53.0 (5.1) | 48.6 (6.1) | |
| (meq/L) | Vehicle | 29.4 (1.9) | 24.6 (0.8) | – | 25.7 (2.3) | 25.7 (2.6) | 29.0 (1.0) |
| ANXA1sp | 29.2 (1.6) | 28.3 (1.2) | – | 23.5 (1.7) | 25.2 (1.9) | 29.8 (1.4) | |
| Hct (%) | Vehicle | 41.4 (2.3) | 25.0 (0.7) | – | 25.0 (1.2) | 28.0 (0.8) | 39.0 (2.9) |
| ANXA1sp | 41.6 (1.9) | 24.2 (0.8) | – | 25.2 (0.8) | 27.4 (2.6) | 38.4 (2.1) |
Values in brackets represent SD (– indicates no values due to the bypass machine being on).
CPB, cardiopulmonary bypass; DHCA, deep hypothermic circulatory arrest.