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. 2017 Aug 30;11:159. doi: 10.3389/fnbeh.2017.00159

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Copyright © 2017 Berlandi, Lin, Ambrée, Rieger, Paulus and Jeibmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan–Meier plots show survival rates of exercising flies compared to non-exercising control groups (A–D). Red lines represent survival curves of exercising groups, black lines show survival curves of non-exercising control groups. Vertical line at day 12 marks the last day of the exercise phase. (A–C) Exercising in the swing boat device did not significantly affect survival of Oregon-R (40.0 days), elav-GAL4 (31.0 days) and UAS-Aβ42/+ (34.0 days) control flies compared to non-exercising controls (Oregon-R: 38.0 days, elav-GAL4: 27.0 days, UAS-Aβ42/+: 35.0 days). (D) Median survival time of exercising AD flies (28.5 days) was significantly longer (***p < 0.001) compared to non-exercising AD flies (21.5 days).