Table 3.

Fluorescence quenching parameters (K_D, dynamic constant; K_S, static constant; K_SV, Stern–Volmer constant) calculated from the quenching of TMA-DPH and DPH by daunorubicin in the different mimetic models at pH 7.4 and 37°C.^a

model	probe	KD (M−1)	KS (M−1)	KSV (M−1)
DMPC	DPH	17 ± 1*	81 ± 2*	98 ± 3*
	TMA-DPH	34 ± 2*	12 ± 1*	45 ± 1*
DMPC : SM	DPH	41 ± 2*	38 ± 4*	80 ± 1*
	TMA-DPH	28 ± 2*	13 ± 2*	42 ± 2*
DMPC : Chol	DPH	8 ± 1	11 ± 1*	19 ± 1*
	TMA-DPH	7 ± 1	∼0*	7 ± 1*
DMPC : SM : Chol	DPH	31 ± 1*	51 ± 1*	82 ± 2*
	TMA-DPH	20 ± 1*	29 ± 1*	49 ± 1*

^aAll values represent the mean ± s.d. (n = 3).

*p < 0.05, statistically different from the other probe, for each biophysical parameter.