Table 3. Nominally significant genetic correlations between cancers and non-cancer traits.
For each cancer-trait genetic correlation observed, current evidence from observational studies and corresponding reference are also listed. P values are not corrected for multiple testing.
| Cancer | Non-cancer trait | rg | se | p | Epidemiological observations | Reference |
|---|---|---|---|---|---|---|
| Breast Cancer | Ulcerative Colitis | 0.243 | 0.08 | 0.002 | + | (55) |
| Breast cancer | Schizophrenia | 0.142 | 0.049 | 0.004 | + | (56) |
| Breast cancer | Height | 0.143 | 0.055 | 0.01 | + | (57) |
| Breast cancer | Triglycerides | -0.13 | 0.061 | 0.033 | - | (58) |
| Breast cancer | BMI | -0.112 | 0.053 | 0.035 | - (premenopausal) + (postmenopausal) |
(35) |
| Colorectal cancer | BMI | 0.157 | 0.046 | 6.22E-04 | + | (35) |
| Colorectal cancer | Triglycerides | 0.126 | 0.058 | 0.029 | + | (59) |
| Colorectal cancer | Schizophrenia | -0.091 | 0.046 | 0.048 | No association | (56) |
| Lung cancer | Ever/Never Smoked | 0.412 | 0.084 | 1.03E-06 | + | (60) |
| Lung cancer | HDL | -0.151 | 0.063 | 0.017 | - | (59) |
| Lung cancer | BMI | 0.116 | 0.054 | 0.032 | - (smokers) No association (non-smokers) |
(35) |
| Ovarian cancer | Type-2 Diabetes | 0.469 | 0.191 | 0.014 | + | (61) |
| Ovarian cancer | Ulcerative Colitis | 0.291 | 0.137 | 0.034 | No association | (55) |
| Pancreatic cancer | HDL | -0.405 | 0.167 | 0.015 | Unknown | N/A |
| Pancreatic cancer | BMI | 0.243 | 0.117 | 0.038 | + | (35) |
| Prostate cancer | BMI | -0.083 | 0.04 | 0.039 | - | (35) |