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. 2017 Sep 4;131(18):2363–2375. doi: 10.1042/CS20171182

Figure 6. TMZ protects RGCs from IOP-induced damage via Nrf2/Ho-1 signaling.

Figure 6

(A,B) Western blot analysis demonstrated that TMZ dramatically induced the nuclear translocation of Nrf2 and increased the expression of Ho-1 in the retinas. (C,D) Treatment with the SnPP significantly blocked the TMZ-mediated neuroprotection in IOP-induced retinal attenuation, especially IPL thickness. (E,F) SnPP dramatically inhibited the TMZ-mediated neuroprotection in IOP-induced RGC apoptosis. (G) SnPP also significantly decreased the inhibitory effect of TMZ on nitrotyrosine production. (H,I) Real-time PCR results confirmed that SnPP significantly suppressed the TMZ-induced decrease in TNFα and IL1β mRNA levels compared with the TMZ only group. The data represent the means ± S.D. (n=8); **P<0.01.