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Protective effect of CpG-A1585 on platelet-activating factor (PAF)-induced lethal shock. (A) Experimental schedule to examine the effect of CpG-A1585 on PAF-induced sudden death. After 1 week of rearing, ICR mice were injected with 50, 100, or 300 µg CpG-A1585 with or without methyl arachidonyl fluorophosphonate (MAFP) (1 mg/kg) 1, 3, and 5 days before receiving 50 µg PAF containing 0.1% human serum albumin. (B) Survival was monitored for 60 min. N = 8 mice per group.
