Table 1. Frequency of tumors with different levels of differentiation in the developmental hierarchy within the xenografts inoculated with PGCC-derived spheroids in SCID mice.
| Group | Diagnosis |
Injection site |
P-value | |
|---|---|---|---|---|
| Subcutaneous (percentage) | Testis (percentage) | |||
| Control | Mixed germ cell tumor | 0 (0) | 0 (0) | |
| High-grade carcinoma | 8 (100) | 8 (100) | ||
| PGCCs | Mixed germ cell tumor | 3 (19.0) | 2 (20.0) | <0.0001 |
| Carcinoma | 13 (81.0) | 8 (80.0) | ||
| High grade | 8 (50) | 5 (50.0) | ||
| Low grade | 0 (0) | 0 (0) | ||
| High grade/low grade | 5 (31.0) | 3 (30.0) | ||
Abbreviations: PGCC, polyploid giant cancer cell; SCID, severe combined immunodeficiency.