Figure 3.

Pluripotent stem cells (PSCs) are more susceptible to interleukin (IL)-2-activated natural killer (NK) cells than resting NK cells. (A) A summary of means and SEM of specific lysis of YAC-1 cells (n = 16), embryonic stem cells (ESCs) (n = 14), induced pluripotent stem cell (iPSCs) (n = 18), and multipotent adult germline stem cell (maGSCs) (n = 16) by freshly purified NK cells (day 0) is shown as determined by ⁵¹Cr-release assays. (B) A summary of means and SEM of specific lysis of YAC-1 cells (n = 12), ESCs (n = 12), iPSCs (n = 12), and maGSCs (n = 12) by IL-2-activated NK cells (day 4) is shown as determined by ⁵¹Cr-release assays. The cytotoxic activity of resting (day 0) and IL-2-activated NK cells (day 4) has been compared for (C) YAC-1 cells and (D) all PSCs together. P-values for the comparisons (2-way-analyses of variance adjusted for E:T ratios) are indicated.