Table 5.

In vitro susceptibility of C. parapsilosis complex species to eight antifungal drugs

	C. parapsilosis (N = 55)					C. metapsilosis (N = 6)					C. orthopsilosis (N = 4)
	Range μg/ml	Mean μg/ml	S %	SDD %	R %	Range μg/ml	Mean μg/ml	S %	SDD %	R %	Range μg/ml	Mean μg/m	S %	SDD %	R %
Fluconazole	0.25–32	2.427	83.64	10.91	5.45	0.5–1	0.833	100	0	0	0.25–0.5	0.437	100	0	0
Itraconazole	0.008–0.5	0.096	83.64	16.36	0	0.016–0.125	0.078	100	0	0	0.016–0.064	0.052	100	0	0
Ketoconazole	0.008–16	0.321	ND	ND	ND	0.008–0.016	0.013	ND	ND	ND	0.008–0.016	0.010	ND	ND	ND
Posaconazole	0.008–1	0.106	ND	ND	ND	0.016–0.08	0.040	ND	ND	ND	0.032–0.08	0.052	ND	ND	ND
Voriconazole	0.008–8	0.190	90.91	7.27	1.82	0.008–0.032	0.018	100	0	0	0.008–0.016	0.010	100	0	0
Caspofungin	0.032–1.5	0.426	100	0	0	0.064–0.25	0.136	100	0	0	0.064–0.25	0.126	100	0	0
Amphotericin B	0.016–1	0.293	100	0	0	0.064–0.5	0.240	100	0	0	0.064–0.25	0.172	100	0	0
5-Flucytosine	0.03–2	0.110	100	0	0	0.03–0.03	0.030	100	0	0	0.03–0.064	0.055	100	0	0

ND Not determined due to lack of validated clinical breakpoints, S susceptible, SDD dose-dependent susceptible, R resistant