Figure EV4. MG132 treatment resulted in a decrease in the mRNA levels but not the protein levels of lamin A and C.

1. MG132 reduces lamin A and lamin C transcript levels. Quantitative real‐time PCR analyses of lamin A and lamin C mRNA levels in HGPS fibroblasts treated with 5 μM MG132.
2. Both lamin A and lamin C protein levels are increased upon HGPS fibroblasts treatment with 5 μM MG132.

Data information: All experiments were performed in triplicate. Results are expressed as mean ± SEM. *P < 0.05, Student's t‐test, **P < 0.01, ***P < 0.001, experimental vs. control (DMSO‐treated cells); the exact P‐values are indicated in Appendix Table S1.